My first suggestion would be to look through the 3Rivers catalog book section. There are a bunch of good books on learning to shoot the bow. These books go into much greater detail than you can get here on such a broad question.
All of the items you mentioned in your list are important to getting good arrow flight. If you look in the Ashby forum there is always a lot of talk about EFOC which means extreme front of center.
It is kind of hard to just write about the items you mentioned. Maybe if you had a specific question about one of them it would be easier to address. Or if you were having a specific problem relating to one of them…
With a 165 head on that rig you need a 500 spine arrow cut to 29 or 30 inchs. Set your brace at 8 1/2 and your nock at 1/2 above. 125 head you will need to leave a 500 carbon at 30 inchs. I posted a pile of stuff on tuning not to long ago. Just search tuning.