As a general rule, I do not shoot with a canted bow. Every once in a great while I take a few practice shots that way just to reinforce that I can do it, but I can probably count those shots every year on both hands. In almost 30 years of bowhunting I can’t remember a single time I needed to cant my bow to kill an animal, and that includes both tree stands and ground hunting. On the other hand, I can recall numerous animals that stopped behind my tree, requiring a vertically-held bow in order to take them.
In the end it’s all about what style of shooting works best for the individual. Some people enjoy a hunched, twisted, bent over, heavily canted bow style of archery. I find my best success implementing more classic archery form. Someone else may find a middle ground approach is most effective for them.
