As long as you put right bevel to rw and left bevel to lw you really want see much of a difference if any at all.
Several years ago when I bought my first set of griz heads they only came in right bevel. I shot lw and didn’t think it would matter. Even though I didn’t loose an animal while using them, I did notice my normal penetration was reduced.
When I told Ed about this he first said it wouldn’t matter. However, after giving it a try in his studies he did find that mixing bevel to wing did make a difference. I can’t remember off the top of my head how much penetration reduction he found, but it was quite a bit.